Endocrine Abstracts

This study examined the effects of maternal diet during late pregnancy and body shape at birth, on postnatal plasma concentrations of IGF1 and leptin.From day 85 of gestation pregnant sows were offered the standard diet (S: n=4) or the S diet plus 30% extra energy derived from either carbohydrate (C: n=5) or palm oil (PO: n=5). Piglets were selected from the normal distribution curve of Ponderal Index (PI: kg/m3), long and thin (Thin<10 <su...

This study examined the effects of maternal diet during late pregnancy and body shape at birth, on postnatal plasma concentrations of IGF1 and leptin.From day 85 of gestation pregnant sows were offered the standard diet (S: n=4) or the S diet plus 30% extra energy derived from either carbohydrate (C: n=5) or palm oil (PO: n=5). Piglets were selected from the normal distribution curve of Ponderal Index (PI: kg/m3), long and thin (Thin<10 <su...

Abnormal foetal growth is associated with an increased predisposition to impaired glucose metabolism (Hales and Barker. Diabetologia 1992; 35: 595-601). The aim of the study was to examine whether size at birth influenced glucose tolerance in pigs at 5 months of age.The litters from 4 multiparous sows were weighed at birth. A low (L: <10th percentile) and normal (N: 40th-60th percentile) piglet was selected from each l...

Increasing energy intakes of sows may decrease the severity of changes in body condition occurring throughout the reproductive cycle and lead to improved efficiency of energy utilisation. The study aimed to examine the effects of feeding extra energy during late pregnancy on body fat deposition, reproductive performance and plasma insulin concentration.Twenty-four multiparous sows were randomly allocated to one of three dietary treatments. From day 85 of...

In humans, pregnancy is considered a diabetogenic event1. A similar situation occurs in sows1. The amount of fat in the sows' diet is inversely correlated to glucose clearance time, thus modifying glucose tolerance2. The aim was to investigate the influence of altered maternal diet during gestation (term = 115days) on the glucose tolerance of the sow. Thirty-four pregnant sows were randomly allocated to 4 isocaloric diets for either the first (G1) or second (G2) 60 days of ges...

In humans, pregnancy is considered a diabetogenic event1. A similar situation occurs in sows1. The amount of fat in the sows' diet is inversely correlated to glucose clearance time, thus modifying glucose tolerance2. The aim was to investigate the influence of altered maternal diet during gestation (term = 115days) on the glucose tolerance of the sow. Thirty-four pregnant sows were randomly allocated to 4 isocaloric diets for either the first (G1) or second (G2) 60 days of ges...

Perinatal nutrition has marked effects on both the health and development of the newborn animal, especially in the case of the intra-uterine growth restricted (IUGR) foetus. IGF-1 and leptin play important roles in the regulation of growth and energy metabolism. The study aimed to examine whether prenatal nutrition influences the growth performance and endocrine profile of IUGR pigs. From day 85 of gestation, pregnant sows were allocated to the standard diet (S: n=4) or the S ...

Background: Birth weight has important consequences for later health, including the development of the metabolic syndrome. Tissue sensitivity to cortisol is regulated, in part, by the GR and alterations in its expression occur in obesity and type 2 diabetes. Low birth weight is associated with increased fat mass and down-regulation of PPARα, in skeletal muscle of neonatal pigs.Objectives: To examine whether birth weight influences GR or PPARα m...

Background: Size at birth has been shown to have important consequences on later health, including the development of the metabolic syndrome. Tissue sensitivity to cortisol is regulated, in part, by the GCR and alterations in GCR expression have been observed in obesity and type 2 diabetes.Objectives: To examine whether birth weight influences the expression of GCR mRNA in skeletal muscle (SM) at days 7 and 14 of postnatal life.Met...

Studies on the lipid emulsion for total parenteral nutrition (TPN) for the premature human infant are limited. We investigated the effects of modifying the fatty acid composition of TPN on the growth and development of the preterm piglet.Piglets delivered by Caesarean section on day 112 of gestation (term = 115 days) received an enteral diet (E: n=6) or TPN solution plus Intralipid (54% 18:2, 25% 18:1; I: n=6) or ClinOleic (17% 18:2, 65% 18:1; C: n=6) fo...